Biomedical Spectrometer | ALPHASCIENCE

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BIOMEDICAL

OxiplexTS Near Infrared, Non-Invasiv, Tissue spectrometer OxiplexTS™ is a revolutionary new device allowing the measurement of oxygenated and de-oxygenated hemoglobin concentrations in tissue. The device works by emitting Near Infrared (NIR) light into tissue at known distances from a collector. Light of two different wavelengths is used and the light is modulated at an RF frequency of 110 MHz. The collected light is measured and processed	Measurements Acquired Using OxiplexTS The plots below show measurements on human calf muscle during exercise. Changes in hemoglobin oxygenation and concentration can be correlated with various clinical conditions. For example, an increase in oxygenated hemoglobin concentration during exercise accompanied by no change or an increase in de-oxygenated hemoglobin concentration may indicate a venous occlusion which restricts the flow of de-oxygenated hemoglobin out of tissue.	Applications of OxiplexTS™ Several areas may benefit from the monitoring of the absolute values of tissue oxygenation, especially when pulse oximetry is not applicable because of the irregularity, or the lack of, the heartbeat, and in all the cases where the tissue oxygenation, and not the arterial oxygen saturation, is the parameter of interest. Therefore, the applications of the OxiplexTS include but are not limited to: • Premature Infant Intensive Care • Sleep Apnea
How Imagent Works Imagent’s working principle is based on the use of near infrared light for probing the cortical surface. The main tissue absorbers in the wavelength region spanning from 700 nm to 900 nm are oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb). On a smaller scale, water, fat and cytochrome oxidase contribute to the partial absorption of the light. The penetration depth of light in tissues is quite significant in this wavelength range. For typical head tissue	Imagent FUNCTIONAL BRAIN IMAGING SYSTEM USING INFRARED PHOTONS Imagent provides a balance between temporal and spatial resolution for the study of superficially located areas of human brain. Imagent detects variations in the oxygenation levels of activated brain areas and provides a map of the areas where the changes occur. The technique is called Diffuse Optical Tomography (DOT).	Operations: • Method: frequency domain • Modulation frequency 110 MHz • Sampling time: minimum xx ms • Number of channels: 4; upgradeable to 16 Measured Parameters: • Changes in [O2Hb] oxygenated hemoglobin • Changes in [HHb] deoxygenated hemoglobin • Changes in [Hb] total hemoglobin Light Sources: • Fiber coupled laser diodes • Wavelengths: 690 nm and 830 nm • Laser power: 10 mW average

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Adult Flexible Sensor The flexible sensor is made from polyurethane rubber in which fiber optics and prisms are embedded. It has been designed for measurements on curved surfaces such as the head. Right hand and left hand versions are available for simultaneous dual head monitoring. The body is larger than the equivalent neonatal head scanner and is thus less susceptible to stray light and background light complications. The sensor may be held in place by medical adhesive that is attached to its surface.	Dual Flexible Sensor Dual Flexible Sensor •• The dual sensor optical probe, utilized for measurements on the forehead, has been developed for measurements that require the simultaneous data acquisition on both frontal lobes of the brain (for instance, sleep apnea, ADHD). The sensor is made of soft and flexible polyurethane and accounts for forehead curvature effects, as well as sampling through the skull into the brain (effective source-detector separation range). The sensor may be attached on the forehead by mean	Infant Flexible Sensor The infant flexible sensor is made from polyurethane rubber in which the fiber optics and prisms are embedded. It has been designed for measurements on curved surfaces such as the head. Right hand and left hand versions are available for simultaneous dual head monitoring. Key Features •Low Profile, Very flexible, Comfortable •Many emitter-detector positions available •Side entry fibers allow for maximum flexibility of the scanner
MRI Compatible Sensors MRI-compatible muscle sensor with optimized for use in a MRI, the fiber length is 10 m and the sensor contains no metal in the sensor body. The sensor body is made from rugged plastic. Key Features •Rugged and versatile for general investigational use •Optimal optical coupling efficiency which allows maximum signal •Maximum accuracy and precision for flat surfaces Key Characteristics •Rigid Plastic Body •Standard emitter-detector distance; 2.0, 2.5, 3.0, 3.5 cm •Custom emitter detector distan	Muscle Sensor The muscle sensor body is made from rugged plastic in which the eight fibers are protected and positioned. It has been optimized for measuring muscle properties at rest as well as during exercise. The body fits the contour of the hand for hand held measurements. Strap attachments allow for measurements during exercise. Key Features •Rugged and versatile for general investigational use •Optimal optical coupling efficiency which allows maximum signal •Hand held or strapped on during exercise	Animal Sensor The animal sensor is for research on small animals (rats, rabbits, pigs, etc.). The sensor consists of a black plastic baseplate, eight 400 μm-diameter core emitter fibers and a collecting 3 mm-diameter fiber bundle. The fiber tips are inserted through the holes in the plastic baseplate; the protruding fiber tips length is easily adjusted to fit the shape of the sample. A rubber gasket holds the fibers in place and provides a spring-like tension to the fibers.
Sensor Pads The sensor pads are advantageous when you only need to study area of the head, such as the motor or visual cortex. Can be used on different subject sizes. Key Features •Flexible foam can be strapped to multiple cranial locations •Fiber depth can be adjusted to ensure contact •The arrangement of emitter-detector distances are easily customize Key Characteristics •Pad is made of ethylene-vinyl acetate •Fibers are 2.5 m •400 um emitter fibers with 3 mm fiber detector bundles	Infant Pad The infant pad is ideal for visual and motor cortex measurements and is made of comfortable ethylene-vinyl acetate (EVA) foam. The pad can be moved to multiple cranial locations and the fiber depth adjusted. Key Features •The arrangement of emitter-detector distances are easily customize •Flexible foam can be strapped to multiple cranial locations •Fiber depth can be adjusted to ensure contact Key Characteristics •Pad is made of ethylene-vinyl acetate •Fibers are 2.5 m •400 um emitter fibers	Helmet The detector helmet allows for the positioning of fibers on the whole head or just an area of interest. The signal from the sources located closer to the detector fibers probe the superficial layer, the signal detected from further distances from the detector bundle probe a deeper region. Therefore it is possible to separate the contribution of the different layers to the signal. The helmet provides several emitter-detector locations. More emitter-detector pairs allow for better localization of

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